Nanocompósitos de cannabis de liberação controlada: uma opção terapêutica e transitória
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Esta proposta visa desenvolver compósitos a partir de canabinóides (CBD) imobilizados em carvões, como um futuro instrumento para a substituição de culturas ilícitas e/ou a abertura de novas linhas económicas na Colômbia, contribuindo para modelos de paz. Para isso, o carbono ativo foi obtido a partir da pirólise de sementes e foi funcionalizado com grupos amina (CAN). Os materiais obtidos foram caracterizados físico-quimicamente. A carga de CBD foi realizada nas brasas e a liberação foi avaliada em condições fisiológicas simuladas, em pH 2,1 (gástrico) e pH 7,4 (intestinal). Os materiais dessorvidos foram colocados em contato com aflatoxinas por 15 minutos a 37°C em meio intestinal para avaliar o duplo efeito dos carbonos. A molécula de CBD tinha maior afinidade com materiais CAN, o que é atribuído a interações deslocalizadas de cátions π. As liberações de CBD foram próximas de 90% no meio gástrico e atingiram 100% no intestino. A remoção de aflatoxinas com CAN foi de 100% a partir de concentrações de 426 μg/L. O carvão permitiu a libertação controlada de CBD e a posterior remoção de aflatoxinas, tornando-se alternativas de valor terapêutico, ao mesmo tempo que contribuiu para a substituição de culturas ilícitas.
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