Controlled-release cannabis nanocomposites: a therapeutic and transitional option
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Abstract
This proposal aims to develop composites from cannabinoids (CBD) immobilized on activated carbons, as a future instrument for the substitution of illicit crops and/or the opening of new economic lines in Colombia, contributing to models of peace. For this, active carbon was obtained from the pyrolysis of seeds and was functionalized with amine groups (CAN). The materials obtained were characterized physicochemically. CBD loading was carried out on the coarbons and the release was evaluated under simulated physiological conditions, at pH 2.1 (gastric) and pH 7.4 (intestinal). The desorbed materials were put in contact with aflatoxins for 15 minutes at 37°C in intestinal medium to evaluate the dual effect of the carbons. The CBD molecule had a higher affinity for CAN materials, which is attributed to delocalized π-cation interactions. CBD releases were close to 90% in the gastric medium and reached 100% in the intestine. The removal of aflatoxins with CAN was 100% from concentrations of 426 μg/L. Carbons allowed the controlled release of CBD and the subsequent removal of aflatoxins, becoming alternatives of therapeutic value, while contributing to the substitution of illicit crops.
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